APOE, or Apolipoprotein E, is a protein generated by the APOE gene, playing a vital role in the packaging and transportation of cholesterol and fats throughout the bloodstream. The APOE gene consists of three prevalent alleles: APOE e2, APOE e3, and APOE e4. APOE e4 is identified as the most potent genetic risk factor for Alzheimer’s disease, whereas APOE e3 is the most common allele. Interestingly, APOE e2 seems to demonstrate a neuroprotective effect against Alzheimer’s.